Six New Phragmalin Limonoids from the Stems of <i>Chukrasia tabularis</i> A. Juss

oleh: Yan-Cui Wang, Fan-Dong Kong, Hao Wang, Wen-Li Mei, Shou-Bai Liu, You-Xing Zhao, Hao-Fu Dai

Format: Article
Diterbitkan: MDPI AG 2018-11-01

Deskripsi

Six new phragmalin limonoids, named moluccensin Z1 (<b>1</b>), moluccensin Z2 (<b>2</b>), carapanolide Y (<b>3</b>), tabulalin N (<b>4</b>), chukvelutilide A1 (<b>5</b>), and velutinasin J (<b>6</b>), as well as two known compounds, chukvelutilide A (<b>7</b>) and velutinasin D (<b>8</b>) were isolated from the stems of <i>Chukrasia tabularis</i> A. Juss. The structures of the new compounds <b>1</b>&#8315;<b>6</b> were confirmed by spectroscopic methods, including IR and HRESIMS, as well as 1D and 2D NMR, and by comparisons with the data of known analogues. All compounds were tested for &#945;-glucosidase and acetylcholinesterase inhibitory activities. However, none of the compounds was active against &#945;-glucosidase and acetylcholinesterase in vitro.