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Soft tissue sarcoma (STS) can arise from any anatomic site and can affect young as well as elderly people. It is a diverse group of more than 60 neoplasms. The most common STS is liposarcoma and the common sites of occurrence are the thigh and retroperitoneum. The rare sites include the head and neck, chest wall and the mediastinum. Here, we report a case of pleomorphic liposarcoma of right side of anterior chest wall in a 62 years old male which was excised and reconstructed using a latissimus dorsi myocutaneous flap.