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The recently discovered Weilasituo Sn-polymetallic deposit in the Great Xing’an Range is an ultralarge porphyry-type deposit. The mineralization is closely associated with an Early Cretaceous quartz porphyry. Analysis of quartz porphyry samples, including zircon U-Pb dating and Hf isotopies, geochemical and molybdenite Re-Os isotopic testing, reveals a zircon U-Pb age of 138.6 ± 1.1 Ma and a molybdenite Re-Os isotopic age of 135 ± 7 Ma, suggesting the concurrence of the petrogenetic and metallogenic processes. The quartz porphyry has high concentrations of SiO₂ (71.57 wt %⁻78.60 wt %), Al₂O₃ (12.69 wt %⁻16.32 wt %), and K₂O + Na₂O (8.85 wt %⁻10.44 wt %) and A/CNK ratios from 0.94⁻1.21, is mainly peraluminous, high-K calc-alkaline I-type granite and is relatively rich in LILEs (large ion lithophile elements, e.g., Th, Rb, U and K) and HFSEs (high field strength elements, e.g., Hf and Zr) and relatively poor in Sr, Ba, P, Ti and Nb. The zircon ε_Hf(t) values range from 1.90 to 6.90, indicating that the magma source materials were mainly derived from the juvenile lower crust and experienced mixing with mantle materials. Given the regional structural evolution history, we conclude that the ore-forming magma originated from lower crust that had thickened and delaminated is the result of the subduction of the Paleo⁻Pacific Ocean. Following delamination, the lower crustal material entered the underlying mantle, where it was partially melted and reacted with mantle during ascent. The deposit formed at a time of transition from post-orogenic compression to extension following the subduction of the Paleo⁻Pacific Ocean.