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Zinc-α2 glycoprotein (ZAG) is an adipokine involved in adipocyte metabolism with potential implications in the pathogenesis of metabolic disorders. Our aim was to evaluate the relationship between visceral (VAT) and subcutaneous adipose tissue (SAT) <i>ZAG</i> expression and metabolic parameters in patients with class III obesity, along with the impact of basal ZAG expression on short- and medium-term outcomes related to bariatric surgery. 41 patients with class III obesity who underwent bariatric surgery were included in this study. <i>ZAG</i> gene expression was quantified in SAT and VAT. Patients were classified into two groups according to SAT and VAT ZAG percentile. Anthropometric and biochemical variables were obtained before and 15 days, 45 days, and 1 year after surgery. The lower basal SAT <i>ZAG</i> expression percentile was associated with higher weight and waist circumference, while the lower basal VAT <i>ZAG</i> expression percentile was associated with higher weight, waist circumference, insulin, insulin resistance, and the presence of metabolic syndrome. Basal SAT <i>ZAG</i> expression was inversely related to weight loss at 45 days after surgery, whereas no associations were found between basal VAT <i>ZAG</i> expression and weight loss after surgery. Additionally, a negative association was observed between basal SAT and VAT <i>ZAG</i> expression and the decrease of gamma-glutamyl transferase after bariatric surgery. Therefore, lower SAT and VAT <i>ZAG</i> expression levels were associated with an adverse metabolic profile. However, this fact did not seem to confer worse bariatric surgery-related outcomes. Further research is needed to assess the clinical significance of the role of <i>ZAG</i> expression levels in the dynamics of hepatic enzymes after bariatric surgery.