Immunomodulatory Effects of Green Tea Polyphenols

oleh: Shuzhen Wang, Zhiliang Li, Yuting Ma, Yan Liu, Chi-Chen Lin, Shiming Li, Jianfeng Zhan, Chi-Tang Ho

Format: Article
Diterbitkan: MDPI AG 2021-06-01

Deskripsi

Green tea and its bioactive components, especially polyphenols, possess many health-promoting and disease-preventing benefits, especially anti-inflammatory, antioxidant, anticancer, and metabolic modulation effects with multi-target modes of action. However, the effect of tea polyphenols on immune function has not been well studied. Moreover, the underlying cellular and molecular mechanisms mediating immunoregulation are not well understood. This review summarizes the recent studies on the immune-potentiating effects and corresponding mechanisms of tea polyphenols, especially the main components of (–)-epigallocatechin-3-gallate (EGCG) and (–)-epicatechin-3-gallate (ECG). In addition, the benefits towards immune-related diseases, such as autoimmune diseases, cutaneous-related immune diseases, and obesity-related immune diseases, have been discussed.