The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
oleh: Zhuoyi Liang, Yi Zhan, Yang Shen, Catherine C. L. Wong, John R. Yates, Florian Plattner, Kwok-On Lai, Nancy Y. Ip
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-10-01 |
Deskripsi
CaMKv is a pseduokinase of unknown function. Here, the authors identify the protein as a substrate of the protein kinase Cdk5, and show that CaMKv is synthesized in response to neural activity and plays an important role in maintaining dendritic spines, synaptic plasticity, and hippocampal memory via RhoA inhibition.