Electrochemical-Induced Cascade Reaction of 2-Formyl Benzonitrile with Anilines: Synthesis of <i>N</i>-Aryl Isoindolinones
oleh: Valerio Morlacci, Tonino Caruso, Marco Chiarini, Antonio Arcadi, Massimiliano Aschi, Laura Palombi
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2022-11-01 |
Deskripsi
An electrochemical initiated tandem reaction of anilines with 2-formyl benzonitrile has been developed. Thus, unprecedented 3-<i>N</i>-aryl substituted isoindolinones have been conveniently achieved by constant current electrolysis in a divided cell using catalytic amount of electricity and supporting electrolyte and a Pt-cathode as working electrode. The origin of the electrochemical activation as well as the mechanism of the subsequent chemical cascade reactions have been investigated by DFT calculations.