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Abstract In this paper, we study the Hopf-zero bifurcation of Oregonator oscillator with delay. The interaction coefficient and time delay are taken as two bifurcation parameters. Firstly, we get the normal form by performing a center manifold reduction and using the normal form theory developed by Faria and Magalhães. Secondly, we obtain a critical value to predict the bifurcation diagrams and phase portraits. Under some conditions, saddle-node bifurcation and pitchfork bifurcation occur along M and N, respectively; Hopf bifurcation and heteroclinic bifurcation occur along H and S, respectively. Finally, we use numerical simulations to support theoretical analysis.