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AIM: To evaluate the efficacy of combined therapy for amblyopia in children by making use of pattern visual evoked potential(P-VEP)game.<p>METHODS: This was a prospective case control study. These asthenopic children were divided into two groups. The control group(66 eyes of 49 patients): occlusive therapy with glasses, cover, precision work, red light treatment and so on, later the stereo vision training was added. The experimental group(72 eyes of 52 patients): conventional methods mentioned above with P-VEP games.<p>RESULTS: The total effective rate and cure rate of experimental group in 6mo were higher than those of control group. The overall effective rate was 94.4% in the experimental group and 83.3% in the control group. There was a statistically significant difference between them(<i>P</i><0.05).<p>CONCLUSION: The comprehensive therapy by making use of P-VEP game is an individualized effective new way in treating amblyopia.