Acetylation regulates ribonucleotide reductase activity and cancer cell growth
oleh: Guo Chen, Yin Luo, Kurt Warncke, Youwei Sun, David S. Yu, Haian Fu, Madhusmita Behera, Suresh S. Ramalingam, Paul W. Doetsch, Duc M. Duong, Michael Lammers, Walter J. Curran, Xingming Deng
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are modulated by acetylation and deacetylation of RRM2 by KAT7 and Sirt2 respectively.