A new mechanism for LKB1 activation

oleh: Szu-Wei Lee, Hui-Kuan Lin

Format: Article
Diterbitkan: Taylor & Francis Group 2018-05-01

Deskripsi

Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) has been thought to be a constitutively active tumor suppressor that is activated by forming an active complex. Very recently, a new post-translational modification on LKB1 was identified that can regulate LKB1 activation and LKB1-mediated cancer cell survival under energy stress.