Flexibilins A–C, New Cembrane-Type Diterpenoids from the Formosan Soft Coral, Sinularia flexibilis
oleh: Ping-Jyun Sung, Lee-Shing Fang, Yueh-Hsiung Kuo, Wei-Hsien Wang, Wan-Ping Hu, Nai-Cheng Lin, Yung-Husan Chen, Tsong-Long Hwang, Michael Yen-Nan Chiang, Mei-Chin Lu, Li-Chung Hu, Jui-Hsin Su
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2013-06-01 |
Deskripsi
Three new cembrane-type diterpenoids, flexibilins A–C (1–3), along with a known cembrane, (−)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1–4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils.