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Local fractional integral inequalities of Hermite-Hadamard type involving local fractional integral operators with Mittag-Leffler kernel have been previously studied for generalized convexities and preinvexities. In this article, we analyze Hermite-Hadamard-type local fractional integral inequalities via generalized (h˜1,h˜2)\left({\tilde{h}}_{1},{\tilde{h}}_{2})-preinvex function comprising local fractional integral operators and Mittag-Leffler kernel. In addition, two examples are discussed to ensure that the derived consequences are correct. As an application, we construct an inequality to establish central moments of a random variable.