Synthesis of the Marine Bromotyrosine Psammaplin F and Crystal Structure of a Psammaplin A Analogue
oleh: Linxiang Zhao, Zuti Wu, Guodong Hu, Sen Yang, Deyang Sun, Dan Liu, Qianjiao Yang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2010-12-01 |
Deskripsi
Psammaplin F, an unsymmetrical disulfide bromotyrosine, was isolated from the sponge Pseudoceratina purpurea in 2003. We reported here the first total synthesis of psammaplin F in 12% overall yield by employing Cleland’s reagent reduction as key step. The longest linear synthetic sequence starting from 3-bromo-4-hydroxybenzaldehyde and hydantoin was seven steps. In addition, a detailed X-ray crystal structure analysis of psammaplin A analogue 8b is given for the first time.