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<p><strong>Background: </strong>Gallstone is a very common gastrointestinal disorder. It is known to produce histopathological changes in the gallbladder. It is also one of the predisposing factors for the development of cancer of gallbladder.</p> <p><strong>Materials and Methods: </strong>This was a retrospective study carried out in the Department of Histopathology, B and B Hospital during a period of 1 year from April 2010 to May 2011. The study included 396 cases of cholecystectomy specimens.</p> <p><strong>Results: </strong>On gross examination, outer gallbladder surface was congested in 116 patients (28%), wall thickness was increased in 181 (45.7%) and mucosal abnormalities were present in 126 (31.6%) patients. At microscopy, epithelial hyperplasia was observed in 183 (46.2%), intestinal metaplasia in 112 (28.2%), dysplasia in 5 (1.3%) and cholesterolosis in 56 (14%) patients.</p> <p><strong>Conclusion: </strong>The pathological changes of the gallbladder epithelium may play an important role in the process of gallstone formation.<strong></strong></p> <p>DOI: <a href="http://dx.doi.org/10.3126/jpn.v2i3.6027">http://dx.doi.org/10.3126/jpn.v2i3.6027</a></p> <p><em>JPN </em>2012; 2(3): 224-225<strong></strong></p>