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Osteoporosis is more common in women, particularly after menopause and may be associated with oral health alterations. The aim of this study was to determine the relationship between periodontal disease and osteoporosis in postmenopausal women. Materials and method: During 2018-2020, 97 menopausal patients were studied, aged between 47 and 76 years: (1) with osteoporosis, mean age 62.42±7.85 years and (2) control group without osteoporosis, mean age 56.80±7.00 years. In group (1), the regions of interest were lumbar spine (L1-L4), proximal femur and mandible. Results: Mean lumbar BMD was 0.87 in group 1, 0.96 in group 2, femoral neck BMD 0.80 in group 1 and 0.88 in group 2, mandibular BMD 1.22 in group 1 and 1.27 in group 2 (p<0.05). Conclusions: Postmenopausal women with osteoporosis are six times more likely to have periodontal disease. Decreased bone mineral density is negatively correlated with the risk of developing periodontal disease.