Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure
oleh: Jeffrey T. Kroetsch, Andrew S. Levy, Hangjun Zhang, Roozbeh Aschar-Sobbi, Darcy Lidington, Stefan Offermanns, Sergei A. Nedospasov, Peter H. Backx, Scott P. Heximer, Steffen-Sebastian Bolz
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-04-01 |
Deskripsi
TNF is typically viewed as an inflammatory mediator. Here the authors identify a non-inflammatory mechanism conserved across species whereby the constitutively expressed smooth muscle cell TNF mediates myogenic signal transduction in skeletal muscle resistance arteries and regulates mean arterial blood pressure.