S1PR1 and VEGFR2 – a synergy that promotes tumor angiogenesis?
oleh: Vijay Avin Balaji Ragunathrao, Vigneshwaran Vellingiri, Mumtaz Anwar, Md Zahid Akhter, Dolly Mehta
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2020-07-01 |
Deskripsi
We have recently uncovered that endothelial cell (EC) S1PR1 controls the effectiveness of VEGFR2 driven tumor angiogenesis. By using tumor ECs, EC-S1PR1−/- mice and S1PR1 antagonist, we showed that VEGF-VEGFR2 pathway requires EC-S1PR1-induced signaling to efficiently drive tumor vascularization and growth, indicating combining S1PR1 antagonist with anti-VEGF/VEGFR2 therapy may eradicate resistant tumors.