One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions
oleh: Xiaoming Ma, Xiaofeng Zhang, Weiqi Qiu, Wensheng Zhang, Bruce Wan, Jason Evans, Wei Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-02-01 |
Deskripsi
A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, <i>N</i>-propargylation, and intramolecular click reactions.