The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
oleh: Caroline Seiler, Amy K. Stainthorp, Sophie Ketchen, Christopher M. Jones, Kate Marks, Philip Quirke, John E. Ladbury
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
The Grb2 splice variant Grb3-3 results in decreased activation of the Ras-MAPK pathway due competition with Grb2 for SOS binding, with reduced Grb3-3 levels observed in tumour tissue suggestive of a mechanism for enhancing Ras pathway activity.