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Lichen sclerosus (LS) is a chronic inflammatory skin disease of genital and extragenital skin. LS is associated with a potential for atrophy, destructive scarring, functional impairment, and malignant evolution. Spontaneous remissions are rare. Therefore, early diagnosis, prompt treatment, and long-term follow-up of affected patients are mandatory. We present a case of 53-year-old man with lichen sclerosus of the glans penis.