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Insight about the impact of malathion on human physiology is still a challenge in environmental health. The present work was focused on the neurotoxic effects of malathion followed by impact of Aloe vera, if any, which is not known. The malathion has significantly altered the levels of the body weight, brain weight and relative weight of the brain. The significant levels of alteration were also observed in the levels of antioxidant potential and oxidative stress biomarkers such as NO, PCO, MDA, GSH, SOD, CAT, GST, and GPx antioxidants. The increased levels of SOD, CAT, GPx and decreased levels of GST were observed in the malathion treated experimental rats. In addition of these, the contents of inflammatory markers such as IL-6, COX-2, TNF-α, and NF-κB were also found to be altered significantly. A significant alteration was also recorded in the activity of AChE. The histological examination of liver tissue sections revealed the severe injury to the central vein and hepatic cords due to malathion toxicity. However, the pre-administration of A. vera markedly ameliorated the neurotoxic effect of malathion. These results suggested that the metabolites present in A. vera may be utilized as a potential and sustainable supplement in the proper management of pesticide induced neurotoxicity in association with the relevant therapeutics.