Amplification of Duffy binding protein-encoding gene allows Plasmodium vivax to evade host anti-DBP humoral immunity
oleh: Jean Popovici, Camille Roesch, Lenore L. Carias, Nimol Khim, Saorin Kim, Amelie Vantaux, Ivo Mueller, Chetan E. Chitnis, Christopher L. King, Benoit Witkowski
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-02-01 |
Deskripsi
Duffy binding protein (DBP) of Plasmodium vivax is important for invasion and is a potential vaccine candidate. Here, the authors show that PvDBP gene amplification protects P vivax in vitro against invasion inhibitory human monoclonal antibodies and is associated to infection of patients with PvDBP binding inhibitory antibodies.