Trefoil factors share a lectin activity that defines their role in mucus
oleh: Michael A. Järvå, James P. Lingford, Alan John, Niccolay Madiedo Soler, Nichollas E. Scott, Ethan D. Goddard-Borger
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-05-01 |
Deskripsi
Trefoil factors (TFFs) protect the mucosa and have various reported binding activities, but whether they share a common interaction mechanism has remained unclear. Here, the authors provide structural and biochemical evidence that all three human TFFs are divalent lectins that recognise the same disaccharide.