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This study aims to explain the participation of ROS in cronic gastric mucosal damage by drinking water with pH 4 and by undergoing 30 minutes for three times per day of water immersion. After four weeks the animals which were exposed at two damaging factors were sacrificed and gastric mucosa was collected for analyzing lipid peroxydation and superoxide dismutase activity. The levels of MDA and 4-HNE used as indicators of lipid peroxidation, increased from 5.85 ± 0.04 nmol/g to 12.25±0.95 nmol/g for acid group and from 5.85 ± 0.04 nmol/g to14.06 ± 1.20 nmol/g for water immersion group. In the acid group the level of total glutathione decresed to 200.10±19.10 mg/100g and 145.56±13.85 mg/100g reduced glutathione. In water immersion group the level of total glutathione decresed to 180.70 ±16.82 mg/100g and 130.60±10.64 mg/100g reduced glutathione. In acid group Superoxide dismutase decreased to 255.18 ± 22.84 U/g and in water immersion group decreased to 215.73 ± 20.60 U/g.