Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma

oleh: Moustafa Abdalla, Danh Tran-Thanh, Juan Moreno, Vladimir Iakovlev, Ranju Nair, Nisha Kanwar, Mohamed Abdalla, Jennifer P. Y. Lee, Jennifer Yin Yee Kwan, Thomas R. Cawthorn, Keisha Warren, Nona Arneson, Dong-Yu Wang, Natalie S. Fox, Bruce J. Youngson, Naomi A. Miller, Alexandra M. Easson, David McCready, Wey L. Leong, Paul C. Boutros, Susan J. Done

Format: Article
Diterbitkan: Nature Portfolio 2017-11-01

Deskripsi

Studying the spatial mutational and gene expression alterations in breast cancer could impact our understanding of breast cancer development. Here, the authors analyse a unique dataset of epithelial samples that highlight potential field cancerisation surrounding the primary tumour.