In-depth mapping of protein localizations in whole tissue by micro-scaffold assisted spatial proteomics (MASP)
oleh: Min Ma, Shihan Huo, Ming Zhang, Shuo Qian, Xiaoyu Zhu, Jie Pu, Sailee Rasam, Chao Xue, Shichen Shen, Bo An, Jianmin Wang, Jun Qu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-12-01 |
Deskripsi
Accurate protein mapping on whole-tissue levels provides critical insights into diseases/therapies. Here, the authors described a novel spatial proteomics method, based on tissue compartmentalization using a 3D-printed micro-scaffold, generated thousands of protein maps across a whole-tissue slice.