Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2Akita/+ Mice.
oleh: Pierre J Guihard, Jiayi Yao, Ana M Blazquez-Medela, Luisa Iruela-Arispe, Kristina I Boström, Yucheng Yao
| Format: | Article |
|---|---|
| Diterbitkan: | Public Library of Science (PLoS) 2016-01-01 |
Deskripsi
Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification. We also find an induction of a complex of serine proteases in the diabetic endothelium, required for the up-regulation of Sox2. Our results suggest that EndMTs contribute to vascular calcification in diabetic arteries.