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Soursop (<i>Annona muricata</i> Lin.) is a plant belonging to the Annonaceae family that has been widely used globally as a traditional medicine for many diseases. In this review, we discuss the traditional use, chemical content, and pharmacological activities of <i>A.muricata</i>. From 49 research articles that were obtained from 1981 to 2021, <i>A.muricata</i>’s activities were shown to include anticancer (25%), antiulcer (17%), antidiabetic (14%), antiprotozoal (10%), antidiarrhea (8%), antibacterial (8%), antiviral (8%), antihypertensive (6%), and wound healing (4%). Several biological activities and the general mechanisms underlying the effects of <i>A.muricata</i> have been tested both in vitro and in vivo. <i>A.muricata</i> contains chemicals such as acetogenins (annomuricins and annonacin), alkaloids (coreximine and reticuline), flavonoids (quercetin), and vitamins, which are predicted to be responsible for the biological activity of <i>A.</i><i>muricata</i>.