Deep transfer learning of cancer drug responses by integrating bulk and single-cell RNA-seq data
oleh: Junyi Chen, Xiaoying Wang, Anjun Ma, Qi-En Wang, Bingqiang Liu, Lang Li, Dong Xu, Qin Ma
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
Single-cell RNA-seq data provide the opportunity to predict drug response in cancer while considering intratumour heterogeneity. Here, the authors develop a deep transfer learning framework - scDEAL - to predict single-cell drug responses in cancer by integrating single-cell and bulk RNA-seq data.