Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation
oleh: Alexis Osseni, Aymeric Ravel-Chapuis, Edwige Belotti, Isabella Scionti, Yann-Gaël Gangloff, Vincent Moncollin, Laetitia Mazelin, Remi Mounier, Pascal Leblanc, Bernard J. Jasmin, Laurent Schaeffer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.