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In medicine, the occurrence of antibiotic resistance was becoming a critical concern. At the same time, traditional synthesis methods of antibacterial agents often lead to environmental pollution due to the use of toxic chemicals. To address these problems, this study applies the green synthesis method to create a novel composite using a polymer blend (M8) consisting of chitosan (CS), polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), and silver nanoparticles. The results show that the highest ratio of AgNO₃:M8 was 0.15 g/60 mL, which resulted in a 100% conversion of Ag⁺ to Ag⁰ after 10 h of reaction at 80 °C. Hence, using M8, Ag nanoparticles (AgNPs) were synthesized at the average size of 42.48 ± 10.77 nm. The AgNPs’ composite (M8Ag) was used to inhibit the growth of <i>Staphylococcus aureus</i> (<i>SA</i>), <i>Pseudomonas aeruginosa</i> (<i>PA</i>), and <i>Salmonella enterica</i> (<i>SAL</i>). At 6.25% dilution of M8Ag, the growth of these mentioned bacteria was inhibited. At the same dilution percentage of M8Ag, <i>PA</i> was killed.