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Al-Mg-Mn-Sc-Zr alloy plates of 5mm thick were welded successfully using Friction stir welding (FSW). Three-factor five-level central composite design was adopted for experimentation. Response surface methodology (RSM) was employed to construct a mathematical regression model. Optimization of FSW process parameters obtained by using response surface plots for maximize hardness, tensile strength, %elongation, impact strength and bending strength, the results were validated with confirmation tests at identified optimum conditions.