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The aim of this study was to evaluate the symptomatic carpal tunnel syndrome frequency among dentists working in Hamadan and to compare with those of physicians and also to determine some other related factors. Our studied population was all dentists and physicians working in Hamadan with at least one year working experience. This study was analytical cross sectional and was performed on 100 dentists whom were matched by age , sex and BMI with control group (physicians). Persons suspected to have symptomatic carpal    tunnel syndrome were examined electrodiagnostically. Results of this study indicated that the frequency of symptomatic carpal tunnel syndrome was higher in dentist rather than physicians working in Hamadan but the difference between this two groups was not statistically significant and there was no relationship between symptomatic carpal tunnel syndrome and age ,    sex and BMI.          There was no relation between back pain and neck pain in dentist working in Hamadan with sex , age and BMI.