Imatinib mesylate in combination with chemotherapy in four children with de novo and advanced stage Philadelphia chromosome-positive acute lymphoblastic leukemia
oleh: José Luis Fuster, Mar Bermúdez, Ana Galera, María Esther Llinares, Doris Calle, Francisco Jose Ortuño
| Format: | Article |
|---|---|
| Diterbitkan: | Ferrata Storti Foundation 2007-12-01 |
Deskripsi
The role of imatinib in childhood Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) has not been established. We treated four children with imatinib in combination with conventional chemotherapy (CT) before stem cell transplantation (SCT). Response evaluation consisted of fluorocytometric analysis of minimal residual disease (MRD) and standard qualitative RT-PCR follow-up.