Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy
oleh: Prathyusha Konda, Liubov M. Lifshits, John A. Roque, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Shashi Gujar
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2021-01-01 |
Deskripsi
We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.