Determinants of synapse diversity revealed by super-resolution quantal transmission and active zone imaging

oleh: Zachary L. Newman, Dariya Bakshinskaya, Ryan Schultz, Samuel J. Kenny, Seonah Moon, Krisha Aghi, Cherise Stanley, Nadia Marnani, Rachel Li, Julia Bleier, Ke Xu, Ehud Y. Isacoff

Format: Article
Diterbitkan: Nature Portfolio 2022-01-01

Deskripsi

Super-resolution quantal imaging relates transmission at excitatory synapses to presynaptic molecular composition. The authors find that evoked transmission varies greatly between synapses and is uncorrelated and physically separate from spontaneous transmission, and identify responsible presynaptic proteins.