Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM
oleh: Runrun Wu, Jeremy W. Bakelar, Karl Lundquist, Zijian Zhang, Katie M. Kuo, David Ryoo, Yui Tik Pang, Chen Sun, Tommi White, Thomas Klose, Wen Jiang, James C. Gumbart, Nicholas Noinaj
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
The β-barrel assembly machinery (BAM) assists the folding and membrane insertion of bacterial outer membrane proteins. Here, the authors report structural characterization of BAM in lipid environment and in complex with the client protein EspP integrated into the barrel of BamA, providing insight into BAM mechanism of function.