Sample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression
oleh: Qing Yu, Xinyue Liu, Mark P. Keller, Jose Navarrete-Perea, Tian Zhang, Sipei Fu, Laura P. Vaites, Steven R. Shuken, Ernst Schmid, Gregory R. Keele, Jiaming Li, Edward L. Huttlin, Edrees H. Rashan, Judith Simcox, Gary A. Churchill, Devin K. Schweppe, Alan D. Attie, Joao A. Paulo, Steven P. Gygi
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2023-02-01 |
Deskripsi
Targeted proteomics enables robust hypothesis-driven research. Here, Yu et al. present a multiplexed approach for targeted pathway proteomics and apply it to quantify protein families across 480 fully genotyped Diversity Outbred mice, revealing impacts of genetic variation on protein expression and lipid metabolism.