Stem cell–nanomedicine system as a theranostic bio-gadolinium agent for targeted neutron capture cancer therapy
oleh: Yen-Ho Lai, Chia-Yu Su, Hung-Wei Cheng, Chao-Yi Chu, Long-Bin Jeng, Chih-Sheng Chiang, Woei-Cherng Shyu, San-Yuan Chen
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
Gadolinium-neutron capture therapy (Gd-NCT) in glioblastoma shows promise but is limited by toxicity and short-half life in the brain. Here, the authors present a magnetised stem cell-nanoparticle system to facilitate brain penetrance of Gd-NCT and demonstrate its utility in an orthotopic rat glioblastoma model.