T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice
oleh: Venetia Bazioti, Anouk M. La Rose, Sjors Maassen, Frans Bianchi, Rinse de Boer, Benedek Halmos, Deepti Dabral, Emma Guilbaud, Arthur Flohr-Svendsen, Anouk G. Groenen, Alejandro Marmolejo-Garza, Mirjam H. Koster, Niels J. Kloosterhuis, Rick Havinga, Alle T. Pranger, Miriam Langelaar-Makkinje, Alain de Bruin, Bart van de Sluis, Alison B. Kohan, Laurent Yvan-Charvet, Geert van den Bogaart, Marit Westerterp
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-07-01 |
Deskripsi
Cholesterol efflux is mediated by specific transporters in T cells. Here the authors show that when the ABCA1/ABCG1 cholesterol transporters are absent, peripheral T cell numbers are reduced but activation increased with a premature aging phenotype of T cell senescence and apoptosis in middle aged Ldlr −/− mice.