Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
oleh: Wei Deng, Yan Xu, Wenchun Chen, David S. Paul, Anum K. Syed, Matthew A. Dragovich, Xin Liang, Philip Zakas, Michael C. Berndt, Jorge Di Paola, Jerry Ware, Francois Lanza, Christopher B. Doering, Wolfgang Bergmeier, X. Frank Zhang, Renhao Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-09-01 |
Deskripsi
The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, leading to platelets clearance.