Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
oleh: Kun Zhao, Yaowang Li, Zhenying Liu, Houfang Long, Chunyu Zhao, Feng Luo, Yunpeng Sun, Youqi Tao, Xiao-dong Su, Dan Li, Xueming Li, Cong Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-05-01 |
Deskripsi
The E46K α-synuclein mutation causes familial Parkinson’s disease. Here, the authors present the cryo-EM structure of N-terminally acetylated E46K α-synuclein fibrils and find that it is distinct from other known α-synuclein fibril structures.