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This paper aims to explore the automatic detection method of epileptic seizures to improve the treatment and diagnosis of medically refractory epilepsy patients. Anew algorithm based on directed transfer function (DTF) method was proposed for epileptic seizure detection. First, the sliding window technique was used to segment electroencephalogram (EEG) recordings, and the cerebral functional connectivity was calculated by the DTF algorithm. Then, the total information outflow based on the DTF-derived connectivity was calculated by adding up the information flow from a single EEG channel to other channels. Finally, the information outflow was assigned as the features of support vector machine (SVM) classifier to discriminate interictal and ictal EEG segments. For 10 epilepsy patients, the proposed algorithm provided the mean correct rate of 98.45%, the mean selectivity of 64.43%, the mean sensitivity of 93.36%, the mean specificity of 98.42%, and the average detection rate of 95.89%. By applying the statistical analysis, the superiority of DTF-based method was statistically significant when compared with other algorithms in terms of five assessment criteria. Our results indicated that the DTF-derived connectivity could characterize the dynamic causal interaction patterns between brain areas during seizure states, and the proposed method was suitable for the detection of epileptic seizures.