Proteome effects of genome-wide single gene perturbations

oleh: Merve Öztürk, Anja Freiwald, Jasmin Cartano, Ramona Schmitt, Mario Dejung, Katja Luck, Bassem Al-Sady, Sigurd Braun, Michal Levin, Falk Butter

Format: Article
Diterbitkan: Nature Portfolio 2022-10-01

Deskripsi

Protein abundance is controlled at the transcriptional, translational and posttranslational levels. Here, Öztürk et al. determine proteome changes resulting from individual knockout of 3308 nonessential genes in the yeast S. pombe, infer gene functionality, and show that protein upregulation under stable transcript expression utilizes optimal codons.