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Cancer is a disease, a public health problem, which is found in the world as well as in Indonesia. In<br />general, some of cancer theraphies are ineffective, characterized by the resistance performance of cancer cell line,<br />the exposed normal cell and by the side effects. Nowadays, studies to fi nd the specifi c and safely anti-cancer<br />drugs were increased by the time. Several studies revealed that Curcuma mangga Val. Rhizome contains some<br />secondary metabolites, essential or non-essential oil, which has cytotoxic activities to the cancer cells. Based<br />on these anti-cancer potentials, this study has several aims to recognize anti-cancer selectivity and molecular<br />mechanism by inducting apoptosis and inhibiting myeloma cell proliferation. To C. mangga Val. essential oil,<br />immunocyto chemical test was performed to determine the expression of p53, caspase-9, Bcl-2, H-Ras protein<br />while TUNEL test was performed to determine the number of apoptosis cells.<br />The results of this study shown that anti-cancer molecular mechanism of C. mangga Val. essential oil to<br />myeloma cell line was performed by increasing apoptosis; by increasing the expression of pro-apoptosis p53,<br />caspase-9 protein and reducing protein which is increasing proliferation Bcl-2 and H-Ras.