Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding
oleh: Daniel J. Christoffel, Jessica J. Walsh, Boris D. Heifets, Paul Hoerbelt, Sophie Neuner, Gordon Sun, Vinod K. Ravikumar, Hemmings Wu, Casey H. Halpern, Robert C. Malenka
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-04-01 |
Deskripsi
Hedonic feeding occurs in the absence of metabolic need and plays a critical role in the excessive feeding that underlies obesity. The authors show that optogenetic manipulation of NAc inputs from the prefrontal cortex versus inputs from the anterior paraventricular nucleus of the thalamus has opposite effects on high fat intake.