Microwave Assisted Synthesis of Some Novel Series of 4-Thiazolidinone Derivatives as Potent Antimicrobial Analogs
oleh: Sainath B Zangade, Avinash Shinde, Yogesh Nalwar, Yeshwant Vibhute
| Format: | Article |
|---|---|
| Diterbitkan: | Universidade Federal de Mato Grosso do Sul 2016-07-01 |
Deskripsi
<p>Several substituted 4‐thiazolidinone derivatives <strong>2a</strong><strong>‐</strong><strong>q</strong> have been synthesized from halogenohydroxy substituted Schiff bases <strong>1a-q</strong> under microwave irradiation technique. The reactions were carried out using ethanol: 2-methoxyethanol mixture as efficient reaction solvent system to afford high yield of product. The structures of newly synthesized compounds have been established on the basis of elemental analysis, IR, <sup>1</sup>H & <sup>13</sup>C NMR and mass spectral data. Further, all newly synthesized compounds were screened for their <em>in vitro</em> antimicrobial activity. The antifungal and antibacterial effects of the tested compounds are due to their molecular structure and substituent present.</p><p> </p><div><p class="orbitaladdress">DOI: <a href="http://dx.doi.org/10.17807/orbital.v8i3.838">http://dx.doi.org/10.17807/orbital.v8i3.838</a></p></div><p> </p><p> </p>