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Objective(s): To evaluate quality of life in adult patients with leukemia  in Shiraz, Iran. Methods: This was a cross-sectional study of 100 patients attending hematology center of Namazi hospital in Shiraz and 100 healthy employee and students of Shiraz University of Medical Sciences. Quality of life was measured using Iranian version of SF-36. Also demographic questions were collected. Results: Patients reported poorer health-related quality of life than controls in almost all measures. However there were no significant differences among patients who were differed in type of leukemia and the disease duration. Conclusion: The need for supportive interventions for this patient population seems necessary.