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Five years of mortality data of impala Aepyceros melampus, blue wildebeest Connochaetes taurinus, buffalo Syncerus caffer and kudu Tragelaphus strepsiceros have been used to describe the minimum mortality profiles of the respective species in an open savanna system with the full compliment of predators. Predation is the principle cause of natural mortalities on the study site, Letaba Ranch, which is adjacent to the Kruger National Park. The principle cause of impala mortality are leopards Panthera pardus and wild dogs Lycaon pictus. Lion Panthera leo were major contributors to the mortality of wildebeest and buffalo. Anthrax Bacillus anthracis was the main cause of kudu mortality.